Personen > Professoren/-innen > Illges, Harald

Illges, Harald

Harald Illges

Prof. Dr. Harald Illges
Professor für Immunologie und Zellbiologie

von-Liebig-Str. 20
53359 Rheinbach
Bauteil A, Raum A 218

Telefon: +49 2241 865 570
FAX: +49 2241 865 8570

mailto:

Lehrveranstaltungen

  • Immunology (BSc Applied Biology)
  • Cell Biology (BSc Applied Biology)
  • Advanced and Clinical Immunology (MSc Biomedical Sciences)

 

Forschungsgebiete

  • Autoimmunität
  • Immundefekte
  • Komplement System
  • Neuroimmunologie

 

Kooperationsfelder

 

Sonderaufgaben (Selbstverwaltung)

  • Beauftragter für Studiengangsorganisation Biology ("Studiendekan Biologie")

 

Veröffentlichungen (seit 2000)

  • Illges, H., M. Braun, H.H. Peter, and I. Melchers. 2000. Reduced expression of the complement receptor type 2 (CR2, CD21) by synovial fluid B and T lymphocytes. Clin Exp Immunol 122:270-276.

  • Denz, A., H. Eibel, H. Illges, G. Kienzle, M. Schlesier, and H.H. Peter. 2000. Impaired up-regulation of CD86 in B cells of "type A" common variable immunodeficiency patients.Eur J Immunol 30:1069-1077.

  • Allam, A., and H. Illges. 2000. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Immunobiology 202:353-362.

  • Schwab, J., and H. Illges. 2001. Regulation of CD21 expression by DNA methylation and histone deacetylation. Int Immunol 13:705-710.

  • Schwab, J., and H. Illges. 2001. Silencing of CD21 expression in synovial lymphocytes is independent of methylation of the CD21 promoter CpG island. Rheumatol Int 20:133-137.

  • Solomon, S., M. Masilamani, L. Rajendran, M. Bastmeyer, C.A. Stuermer, and H. Illges. 2002. The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs. Immunobiology 205:108-119.

  • Solomon, S., C. Kolb, S. Mohanty, E. Jeisy-Walder, R. Preyer, V. Schollhorn, and H. Illges. 2002. Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35). Eur J Immunol 32:644-651.

  • Shen, H., H. Illges, A. Reuter, and C.A. Stuermer. 2002. Cloning, expression, and alternative splicing of neogenin1 in zebrafish. Mech Dev 118:219-223.

  • Mierau, R., and H. Illges. 2002. Autoantibodies and the complement system--significance for pathogenesis of rheumatoid arthritis?. Z Rheumatol 61:460-463.

  • Masilamani, M., E. von Seydlitz, M. Bastmeyer, and H. Illges. 2002. T cell activation induced by cross-linking CD3 and CD28 leads to silencing of Epstein-Barr virus/C3d receptor (CR2/CD21) gene and protein expression. Immunobiology 206:528-536.

  • Masilamani, M., H.J. Apell, and H. Illges. 2002. Purification and characterization of soluble CD21 from human plasma by affinity chromatography and density gradient centrifugation. J Immunol Methods 270:11-18.

  • Kassahn, D., C. Kolb, S. Solomon, P. Bochtler, and H. Illges. 2002. Few human autoimmune sera detect GPI. Nat Immunol 3:411-412.

  • Illges, H. 2002. Die Rolle der Komplementpfade, Fc-Rezeptoren und Antikörper in einem Rheumamodell. Immunologie Aktuell 2:179-181.

  • Rajendran, L., M. Masilamani, S. Solomon, R. Tikkanen, C.A. Stuermer, H. Plattner, and H. Illges. 2003. Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells. Proc Natl Acad Sci U S A 100:8241-8246.

  • Mohanty, S., S.M. Weiner, R. Mentele, P. Vaith, F. Lottspeich, and H. Illges. 2003. Human IgG1/IgG3 cryoglobulin suggesting lack of allelic exclusion. Mol Immunol 39:1003-1011.

  • Masilamani, M., D. Kassahn, S. Mikkat, M.O. Glocker, and H. Illges. 2003. B cell activation leads to shedding of complement receptor type II (CR2/CD21). Eur J Immunol 33:2391-2397.

  • Deininger, S.O., L. Rajendran, F. Lottspeich, M. Przybylski, H. Illges, C.A. Stuermer, and A. Reuter. 2003. Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons. Mol Cell Neurosci 22:544-554.

  • Wehr, C., H. Eibel, M. Masilamani, H. Illges, M. Schlesier, H.H. Peter, and K. Warnatz. 2004. A new CD21low B cell population in the peripheral blood of patients with SLE. Clin Immunol. 113(2):161-71.

  • Solomon, S., M. Masilamani, S. Mohanty, J.E. Schwab, E.M. Boneberg, and H. Illges. 2004. Generation of three-dimensional pannus-like tissues in vitro from single cell suspensions of synovial fluid cells from arthritis patients. Rheumatol Int 24:71-76.

  • Masilamani, M., J. von Kempis, and H. Illges. 2004. Decreased levels of serum soluble complement receptor-II (CR2/CD21) in patients with rheumatoid arthritis. Rheumatology (Oxford) 43:186-190.

  • Masilamani, M., R. Nowack, T. Witte, M. Schlesier, K. Warnatz, M.O. Glocker, H.H. Peter, and H. Illges. 2004. Reduction of Soluble Complement Receptor II/CD21 in Systemic Lupus Erythomatosus and Sjoegren´s Syndrome but not Juvenile Arthritis. Scand J Immunol 60(6):625-30.

  • Klett, V., E.M. Boneberg, K. Trenz, R. Knippers, and H. Illges. 2004. Hydrostatic pressure induces apoptosis in the human leukemic T cell line Jurkat via the mitochondrial pathway. Scand J Immunol 60(4):403-11.

  • Grottentaler, T., J. von Kempis, S. Goldacker and H. Illges. 2006. Soluble CD21 in sera and synovial fluid of arthritic patients. Rheumatol Int., 26 (3): 240-3.

  • Melanie M. Hoefer, Annette Aichem, Madhan Masilamani and Harald Illges. 2004. Complement receptor type II (CR2/CD21), a receptor with multiple functions. Karger, in press

  • Hu, H., H. Illges, C. Gruss, and R. Knippers. 2005. Distribution of the chromatin-protein DEK on an active and inactive CD21/CR2 gene in two B lymphocyte cell lines. Int Immunol 17(6):789-96.

  • Solomon, S., D. Kassahn, and H. Illges. 2005. The role of the complement and the FcγR system in the pathogenesis of arthritis. Arthritis Rheum Therapy 7(4):129-35.

  • Steffen Möller, Eilhard Mix, Martin Blüggel, Pablo Serrano-Fernández, Dirk Koczan, Vasilis Kotsikoris, Manfred Kunz, Michael Watson, Jens Pahnke, Harald Illges, Michael Kreutzer, Stefan Mikkat, Hans-Jürgen Thiesen, Michael O. Glocker, Uwe K. Zettl and Saleh M. Ibrahim. 2005. Collection of soluble variants of membrane proteins for transcriptomics and proteomics. In Silico Biology 5, 0028.

  • Spohn, G., K. Schwarz, P. Maurer, H. Illges, N. Rajasekaran, Y. Choi, G.T. Jennings, and M.F. Bachmann. 2005. Protection against osteoporosis by active immunization with TRANCE/RANKL displayed on virus-like particles. J Immunol, 175 (9) 6211-8.

  • S. Solomon, N. Rajasekaran, E. Jeisy-Walder, S. B. Snapper and H. Illges. 2005. A crucial role for macrophages in the pathology of K/BxN sera induced arthritis. Eur J Immunol, 7 (4) 129-35.

  • Hoefer MM, Boneberg EM, Grotegut S, Kusch J and H. Illges. 2006 Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation. Int J Biol Macromol. 2006 Mar 16

  • Boneberg EM, von Seydlitz E, Propster K, Watzl H, Rockstroh B. and H. Illges. 2006. D3 dopamine receptor mRNA is elevated in T cells of schizophrenic patients whereas D4 dopamine receptor mRNA is reduced in CD4(+)-T cells. J Neuroimmunol 173:180-187.

  • Aichem A, Masilamani M, Illges H. 2006. Redox-regulation of CD21-shedding involves signaling via PKC and indicates the formation of a juxtamembrane stalk. J Cell Sci, 119:2892-2902.

  • Sengstake S., Boneberg, E-M and Illges H. 2006. CD21 and CD62L shedding are both inducible via P2X7Rs. Int Immunol 18:1171-1178.

  • Hoefer, M.M., E.M. Boneberg, S. Grotegut, J. Kusch, and H. Illges. 2006. Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation. Int J Biol Macromol 38:259-267.

  • Rajendran L. Soazig L.L., Illges, H. 2007. Raft association and lipid droplet targeting of flotillins are independent of Caveolin-1. Biol Chem 388:307-314.

  • Kneilling, M., Hültner, L., Pichler, B., Mailhammer, R., Morawietz, L., Solomon, S., Eichner, M., Sabatino, J., Biedermann, T., Krenn, V.,Weber, V.A., Illges, H., Haubner, R, Röcken, M. 2007. Targeted Mast Cell-Silencing silencing protects against joint destruction and angiogenesis in experimental arthritis in mice. Arthritis Rheum 56:1806-1816.

  • Singh, A., M. Blank, Y. Shoenfeld, and H. Illges. 2008. Antiphospholipid syndrome patients display reduced titers of soluble CD21 in their sera irrespective of circulating anti-beta-2-glycoprotein-I autoantibodies. Rheumatol Int. 2008 May;28(7):661-5.

  • Melanie M. Hoefer, Annette Aichem, Andrew M. Knight and H. Illges. 2008. Modulation of murine complement receptor type 2 (CR2/CD21) ectodomain shedding by its cytoplasmic domain. Mol Immunol. 2008 Apr;45(8):2127-37.

  • Masilamani, M., N. Rajasekaran, A. Singh, H. Low, K. Albus, S. Anders, F. Behne, P. Eiermann, K. König, C. Mindnich, T.P. Ribarska, and H. Illges. 2008. Systemic reduction of soluble complement receptor II/CD21 during pregnancy to levels reminiscent of autoimmune disease. Rheumatol Int. 2008 Sep;28(11):1137-41.
  • Kienbaum, M. Koy, C., Montgomery, H.V., Drynda, H., Lorenz, P., Illges, H., Tanaka, K., Kekow, J., Guthke, R., Thiesen, H.-J., and M.O. Glocker. 2009. Mass Spectrometric Characterization of Apheresis Samples from Rheumatoid Arthritis Patients leads to Knowledge-based Considerations for Improvements of Plasmapheresis Therapy.

    Proteomics Clin. Appl. 2009, 3, 1-14.

  • Hoefer, M. M. and Illges, H. 2009. Ectodomain shedding and generation of two carboxy-terminal fragments of human complement receptor 2/CD21. Mol Immunol 46, 2630-2639.

  • Boneberg E.M., Illges H., Legler D.F., Fürstenberger G. 2009. Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvascular Research, 2009 Dec;78(3):325-31. Epub 2009 Jul 15.

  • Narendiran Rajasekaran, Samuel Solomon, Miroslav Gajda, Hiroshi Ohtsu, Takeshi Watanabe, Rolf Bräuer, Harald Illges.Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis. Int Immunol. 2009 Nov; 21(11):1263-8

  • Rajendran, L., Beckmann, J., Magenau, A., Boneberg, E-M.,Gaus, K., Viola, A, Giebel4, B. and H. Illges. 2009. Flotillins are involved in the polarization of primitive and mature hematopoietic cells. PLOS 2009 Dec 22;4(12):e8290.

Persönlicher Werdegang

  • Studium der Biologie an der Universität Köln (Diplom und Promotion)
  • Postdoctoral fellow (DFG Stipendium) an der University of Alabama, Birmingham, USA
  • Wissenschaftlicher Mitarbeiter an der Universitätsklinik Freiburg
  • Gruppenleiter an der Universität Konstanz
  • Habilitation an der Universität Konstanz für das Fach Immunologie
  • Gründung und Leitung des Biotechnologie Instituts Thrugau, Schweiz
  • Professor für Immunologie und Zellbiologie an der Fachhochschule Bonn-Rhein-Sieg